Highlighted Publications
i) Schroeder BO. Fight them or feed them: how the intestinal mucus layer manages the gut microbiota. Gast. Report 7(1), 3-12. (2019) PMID30792861
ii) Schroeder BO, Birchenough GMB, Ståhlman M, Arike L, Johansson MEV, Hansson GC and Bäckhed F. Bifidobacteria or fiber protect against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host & Microbe 23, 1-14. (2018) PMID29276171
iii) Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat. Medicine 22, 1079–1089. (2016) PMID27711063
iv) Schroeder BO, Ehmann D, Precht J, Küchler R, Castillo PA, Berger J, Schaller M, Stange EF, and Wehkamp J. Human alpha-defensin 6 (HD-6) is an antimicrobial peptide. Muc. Immunol. 8(3), 661-671. (2015) PMID25354318
v) Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 469, 419-423. (2011) PMID21248850
All Publications
2023
24)
Naama M, Telpaz S, Awad A, Ben-Simon S, Harshuk-Shabso S, Modilevsky S, Rubin E, Sawaed J, Zelik L, Zigdon M, Asulin N, Turjeman S, Werbner M, Wongkuna S, Feeney R, Schroeder BO, Nyska A, Nuriel-Ohayon M, Bel S. Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress.
Cell Host & Microbe Online(2023)
2022
23) Schroeder BO. Outlook on the gut microbiota (Editorial). Gast. Report 10 goac024 (2022) PMID35663149
2020
22) Schroeder BO, Birchenough GMB, Pradhan M, Nyström EEL, Henricsson M, Hansson GC and Bäckhed F. Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J Biol Chem 295: 15712 (2020) PMID32900852
21) Puértolas-Balint F and Schroeder BO. Does an Apple a Day Also Keep the Microbes Away? The Interplay Between Diet, Microbiota, and Host Defense Peptides at the Intestinal Mucosal Barrier. Front. Immunol. 11:1164. doi: 10.3389/fimmu.2020.01164 (2020) PMID: 32655555
20) Keipert S, Lutter D, Schroeder BO, Brandt D, Ståhlman M, Schwarzmayr T, Graf E, Fuchs H, de Angelis MH, Tschöp MH, Rozman J, Jastroch M. Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice. Nat Commun. 11(1):624. (2020) PMID: 32005798
2019
19) Stange EF & Schroeder BO. Microbiota and mucosal defense in IBD: an update. Expert Rev. Gastroenterol. Hepatol. 13(10):963-976. (2019) PMID: 31603356
18) Volk JK, Nyström EEL, van der Post S, Abad BM, Schroeder BO, Johansson Å, Svensson F, Jäverfelt S, Johansson MEV, Hansson GC, Birchenough GMH. The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function. J Exp Med. 216 (11):2602-2618. (2019) PMID: 31420376
17) Birchenough GMB, Schroeder BO, Bäckhed F and Hansson, GC. Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier. Gut Microbes 10:2, 246-250. (2019) PMID30252606
16) Wendler J*, Schroeder BO*, Ehmann D, Koeninger L, Mailänder-Sánchez D, Lemberg C, Wanner S, Schaller S, Stange EF, Malek N, Weidenmaier C, LeibundGut-Landmann S, Wehkamp J. Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide. Sci. Rep. 6;9(1):3640. (2019) PMID30842543 (*contributed equally)
15) Schroeder BO. Fight them or feed them: how the intestinal mucus layer manages the gut microbiota. Gast. Report 7(1), 3-12. (2019) PMID30792861
2018
14) Wendler J, Ehmann D, Courth L, Schroeder BO, Malek NP, Wehkamp J. Bacterial periplasmic oxido-reductases are essential for the activity of oxidized human antimicrobial β-defensin 1. Infect. Immun. 86 (4), e00875-17. (2018) PMID29378796
13) Schroeder BO, Birchenough GMB, Ståhlman M, Arike L, Johansson MEV, Hansson GC and Bäckhed F. Bifidobacteria or fiber protect against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host & Microbe 23, 1-14. (2018) PMID29276171
2016
12) Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Nat. Acad. Sci. USA 113(48):13833-13838. (2016) PMID27849619
11) Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat. Medicine 22, 1079–1089. (2016) PMID27711063
2015
10) Hein KZ, Takahashi H, Tsumori T, Yasui Y, Nanjoh Y, Toga T, Wu Z, Grötzinger J, Jung S, Wehkamp J, Schroeder BO, Schroeder JM, Morita E. Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide. Proc. Nat. Acad. Sci. USA 112(42): 13039-44. (2015) PMID26438863
09) Schroeder BO, Ehmann D, Precht J, Küchler R, Castillo PA, Berger J, Schaller M, Stange EF, and Wehkamp J. Human alpha-defensin 6 (HD-6) is an antimicrobial peptide. Muc. Immunol. 8(3), 661-671. (2015) PMID25354318
2013
08) Nuding S, Gersemann M, Hosaka Y, Konietzny S, Schaefer C, Beisner J, Schroeder BO, Ostaff MJ, Saigenji K, Ott G, Schaller M, Stange EF, Wehkamp J. Gastric antimicrobial peptides fail to eradicate Helicobacter pylori infection due to selective induction and resistance. PLoS One 8(9):e73867. (2013) PMID24040100
07) Küchler R, Schroeder BO, Jaeger SU, Stange EF, Wehkamp J. Antimicrobial activity of high-mobility group box 2: a new function to a well-known protein. Antimicrob. Agents Chemother. 57(10):4782-93. (2013) PMID23877675
06) Jaeger SU, Schroeder BO, Meyer-Hoffert U, Fehr SN, Courth L, Gersemann M, Stange EF and Wehkamp J. Cell-mediated reduction of human β-defensin 1: A major role for mucosal thioredoxin. Muc. Immunol. 6(6),1179-90. (2013) PMID23571504
2012
05) Schroeder BO, Stange EF and Wehkamp J. Humanes Beta-Defensin 1: Aus der Defensive gelockt. Z. Gastroenterol. 50(11), 1171-1175. (2012) PMID23150110
04) Troge A, Scheppach W, Schroeder BO, Rund SA, Heuner K, Wehkamp J, Stange EF, Oelschlaeger TA. More than a marine propeller – the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus. Int. J. Med. Microbiol. 302(7-8), 304-314. (2012) PMID23131416
2011
03) Schroeder BO, Stange EF and Wehkamp J. Waking the wimp: Redox modulation activates human beta-defensin 1. Gut Microbes 2(4), 262-266. (2011) PMID21983064
02) Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 469, 419-423. (2011) PMID21248850
2009
01) Möndel M, Schroeder BO, Zimmermann K, Huber H, Nuding S, Beisner J, Fellermann K, Stange EF,
Wehkamp J. Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans. Muc. Immunol. 2(2), 166-172. (2009) PMID19129752
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