Highlighted Publications
i) Holmberg SM*, Feeney RH*, Prasoodanan PK V*, Puértolas-Balint F, Singh DK, Wongkuna S, Zandbergen L, Hauner H, Brandl B, Nieminen AI, Skurk T & Schroeder BO. The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids. Nat. Communications 15, 3502 (2024) PMID38664378(*contributed equally)
ii) Schroeder BO. Fight them or feed them: how the intestinal mucus layer manages the gut microbiota. Gast. Report 7(1), 3-12. (2019) PMID30792861
iii) Schroeder BO, Birchenough GMB, Ståhlman M, Arike L, Johansson MEV, Hansson GC and Bäckhed F. Bifidobacteria or fiber protect against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host & Microbe 23, 1-14. (2018) PMID29276171
iv) Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat. Medicine 22, 1079–1089. (2016) PMID27711063
v) Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 469, 419-423. (2011) PMID21248850
All Publications
2025
34) Wongkuna S, Prasoodanan PK V, Holmberg SM, Bjørnshave A and Schroeder BO. Milk-derived casein glycomacropeptide improves colonic mucus function under Western-style diet feeding in a sialylation-dependent manner. Food Res. Internat. 221(1) (117206) (2025) PMID: 41370273
33) Puértolas-Balint F, Prasoodanan PK V, Holmberg SM and Schroeder BO. Disentangling the Impact of Obesity, Diet, Host Factors, and Microbiota on Small Intestinal Antimicrobial Peptide Expression. Gut Microbes 17, 1 (2536095) (2025) PMID40760765
32) Solowiej-Wedderburn J, Pentz JT, Lizana L, Schroeder BO, Lind P, Libby E. Competition and cooperation: The plasticity of bacteria interactions across environments. PLoS Computational Biology 21(7):e1013213 (2025) PMID40705801
31) Ölander M, Rea Vázquez D, Meier K, Singh A, Silva de Sousa A, Puértolas-Balint F, Milivojevic M, Mooij L, Fredlund J, Calpe Bosch E, Rayón Díaz M, Lundgren M, van der Wal K, Zhu S, Mateus A, Schroeder BO, Lohman JR, Sixt BS. A multi-strategy antimicrobial discovery approach reveals new ways to treat Chlamydia. PLoS Biology 23(4):e3003123 (2025) PMID40299795
2024
30) Löwenmark T, Köhn L, Kellgren T, Rosenbaum W, Bronnec V, Löfgren-Burström A, Zingmark C, Larsson P, Dahlberg M, Schroeder BO, Nyunt Wai S, Ljuslinder I, Edin S, Palmqvist R. Parvimonas micra forms a distinct bacterial network with oral pathobionts in colorectal cancer patients. Journal of Translational Medicine 22, 947 (2024) PMID39420333
29) Sawaed J*, Zelik L*, Levin Y, Feeney R, Naama M, Gordon A, Zigdon M, Rubin E, Telpaz S, Modilevsky S, Ben-Simon S, Awad A, Harshuk-Shabso S, Nuriel-Ohayon M, Werbner M, Schroeder BO, Erez A, Bel S. Antibiotics damage the colonic mucus barrier in a microbiota-independent manner. Science Advances 10, eadp4119 (2024) PMID39259805(*contributed equally)
28) Krigul KL*, Feeney RH*, Wongkuna S, Aasmets O, Holmberg SM, Andreson R, Puértolas-Balint F, Pantiukh K, Sootak L, Org T, Tenson T, Org E#, Schroeder BO# . A history of repeated antibiotic usage leads to microbiota-dependent mucus defects. Gut Microbes 16, 1 (2377570) (2024) PMID39034613 (*contributed equally; #contributed equally)
27) Holmberg SM*, Feeney RH*, Prasoodanan PK V*, Puértolas-Balint F, Singh DK, Wongkuna S, Zandbergen L, Hauner H, Brandl B, Nieminen AI, Skurk T & Schroeder BO. The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids. Nat. Communications 15, 3502 (2024) PMID38664378 (*contributed equally)
2023
26) Puértolas-Balint F and Schroeder BO. Intestinal α-defensins play a minor role in modulating the small-intestinal microbiota composition as compared to diet. Microbiology Spectrum 11(3):e0056723 (2023) PMID37039638
25) Naama M, Telpaz S, Awad A, Ben-Simon S, Harshuk-Shabso S, Modilevsky S, Rubin E, Sawaed J, Zelik L, Zigdon M, Asulin N, Turjeman S, Werbner M, Wongkuna S, Feeney R, Schroeder BO, Nyska A, Nuriel-Ohayon M, Bel S. Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress. Cell Host & Microbe 31(3):433-446.e4. (2023) PMID36738733
24) Birchenough GMB*, Schroeder BO*, Sharba S, Arike L, Recktenwald CV, Puértolas-Balint F, Subramani MV, Hansson KT, Yilmaz B, Lindén SK, Bäckhed F, Hansson GC. Muc2-Dependent Microbial Colonization of the Jejunal Mucus Layer is Diet Sensitive and Confers Resistance to Enteric Pathogen Infection. Cell Reports 42(2):112084. (2023) PMID36753416 (*contributed equally)
2022
23) Schroeder BO. Outlook on the gut microbiota (Editorial). Gast. Report 10 goac024 (2022) PMID35663149
2020
22) Schroeder BO, Birchenough GMB, Pradhan M, Nyström EEL, Henricsson M, Hansson GC and Bäckhed F. Obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. J Biol Chem 295: 15712 (2020) PMID32900852
21) Puértolas-Balint F and Schroeder BO. Does an Apple a Day Also Keep the Microbes Away? The Interplay Between Diet, Microbiota, and Host Defense Peptides at the Intestinal Mucosal Barrier. Front. Immunol. 11:1164. doi: 10.3389/fimmu.2020.01164 (2020) PMID: 32655555
20) Keipert S, Lutter D, Schroeder BO, Brandt D, Ståhlman M, Schwarzmayr T, Graf E, Fuchs H, de Angelis MH, Tschöp MH, Rozman J, Jastroch M. Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice. Nat Commun. 11(1):624. (2020) PMID: 32005798
2019
19) Stange EF & Schroeder BO. Microbiota and mucosal defense in IBD: an update. Expert Rev. Gastroenterol. Hepatol. 13(10):963-976. (2019) PMID: 31603356
18) Volk JK, Nyström EEL, van der Post S, Abad BM, Schroeder BO, Johansson Å, Svensson F, Jäverfelt S, Johansson MEV, Hansson GC, Birchenough GMH. The Nlrp6 inflammasome is not required for baseline colonic inner mucus layer formation or function. J Exp Med. 216 (11):2602-2618. (2019) PMID: 31420376
17) Birchenough GMB, Schroeder BO, Bäckhed F and Hansson, GC. Dietary destabilisation of the balance between the microbiota and the colonic mucus barrier. Gut Microbes 10:2, 246-250. (2019) PMID30252606
16) Wendler J*, Schroeder BO*, Ehmann D, Koeninger L, Mailänder-Sánchez D, Lemberg C, Wanner S, Schaller S, Stange EF, Malek N, Weidenmaier C, LeibundGut-Landmann S, Wehkamp J. Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide. Sci. Rep. 6;9(1):3640. (2019) PMID30842543 (*contributed equally)
15) Schroeder BO. Fight them or feed them: how the intestinal mucus layer manages the gut microbiota. Gast. Report 7(1), 3-12. (2019) PMID30792861
2018
14) Wendler J, Ehmann D, Courth L, Schroeder BO, Malek NP, Wehkamp J. Bacterial periplasmic oxido-reductases are essential for the activity of oxidized human antimicrobial β-defensin 1. Infect. Immun. 86 (4), e00875-17. (2018) PMID29378796
13) Schroeder BO, Birchenough GMB, Ståhlman M, Arike L, Johansson MEV, Hansson GC and Bäckhed F. Bifidobacteria or fiber protect against diet-induced microbiota-mediated colonic mucus deterioration. Cell Host & Microbe 23, 1-14. (2018) PMID29276171
2016
12) Bergström JH, Birchenough GM, Katona G, Schroeder BO, Schütte A, Ermund A, Johansson ME, Hansson GC. Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16. Proc. Nat. Acad. Sci. USA 113(48):13833-13838. (2016) PMID27849619
11) Schroeder BO, Bäckhed F. Signals from the gut microbiota to distant organs in physiology and disease. Nat. Medicine 22, 1079–1089. (2016) PMID27711063
2015
10) Hein KZ, Takahashi H, Tsumori T, Yasui Y, Nanjoh Y, Toga T, Wu Z, Grötzinger J, Jung S, Wehkamp J, Schroeder BO, Schroeder JM, Morita E. Disulphide-reduced psoriasin is a human apoptosis-inducing broad-spectrum fungicide. Proc. Nat. Acad. Sci. USA 112(42): 13039-44. (2015) PMID26438863
09) Schroeder BO, Ehmann D, Precht J, Küchler R, Castillo PA, Berger J, Schaller M, Stange EF, and Wehkamp J. Human alpha-defensin 6 (HD-6) is an antimicrobial peptide. Muc. Immunol. 8(3), 661-671. (2015) PMID25354318
2013
08) Nuding S, Gersemann M, Hosaka Y, Konietzny S, Schaefer C, Beisner J, Schroeder BO, Ostaff MJ, Saigenji K, Ott G, Schaller M, Stange EF, Wehkamp J. Gastric antimicrobial peptides fail to eradicate Helicobacter pylori infection due to selective induction and resistance. PLoS One 8(9):e73867. (2013) PMID24040100
07) Küchler R, Schroeder BO, Jaeger SU, Stange EF, Wehkamp J. Antimicrobial activity of high-mobility group box 2: a new function to a well-known protein. Antimicrob. Agents Chemother. 57(10):4782-93. (2013) PMID23877675
06) Jaeger SU, Schroeder BO, Meyer-Hoffert U, Fehr SN, Courth L, Gersemann M, Stange EF and Wehkamp J. Cell-mediated reduction of human β-defensin 1: A major role for mucosal thioredoxin. Muc. Immunol. 6(6),1179-90. (2013) PMID23571504
2012
05) Schroeder BO, Stange EF and Wehkamp J. Humanes Beta-Defensin 1: Aus der Defensive gelockt. Z. Gastroenterol. 50(11), 1171-1175. (2012) PMID23150110
04) Troge A, Scheppach W, Schroeder BO, Rund SA, Heuner K, Wehkamp J, Stange EF, Oelschlaeger TA. More than a marine propeller – the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus. Int. J. Med. Microbiol. 302(7-8), 304-314. (2012) PMID23131416
2011
03) Schroeder BO, Stange EF and Wehkamp J. Waking the wimp: Redox modulation activates human beta-defensin 1. Gut Microbes 2(4), 262-266. (2011) PMID21983064
02) Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J. Reduction of disulphide bonds unmasks potent antimicrobial activity of human beta-defensin 1. Nature 469, 419-423. (2011) PMID21248850
2009
01) Möndel M, Schroeder BO, Zimmermann K, Huber H, Nuding S, Beisner J, Fellermann K, Stange EF,
Wehkamp J. Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans. Muc. Immunol. 2(2), 166-172. (2009) PMID19129752
Bjoern O. Schroeder lab at Umeå University 