Mucus defects in genetically obese mice!
In our latest manuscript we show that obesity-associated microbiota contributes to mucus layer defects in genetically obese mice. While it was previously thought that gut microbiota deteriorate the mucus layer only in the absence of dietary fibre, we now describe that genetically obese mice have a similar mucus defect in the large intestine, even when the diet contains a lot of fibre. Find the full story now published in the Journal of Biological Chemistry .
After defeating several obstacles due to the COVID19 pandemic, Sophia Geiger finally joined the lab in September as a rotation student. Sophia studies biochemistry at the University of Tübingen in Germany and will support the team with her biochemical expertise and her background on nutrition. Directly after joining the lab, she was already curious how intestinal mucus looks like under the microscope. Find more information about Sophia and the rest of the current group in our Team section!
Welcome Liv and Elin!
This summer Liv and Elin joined the group as “Forskaraspiranterna“, an undergrad fellowship program from the Medical Faculty. As Forskaraspiranterna Elin and Liv will actively join the group in three consecutive summers and get first hands-on lab experience to complete their own research projects. Learn more about the two Forskaraspiranterna in our Team section!
Does an Apple a Day Also Keep the Microbes Away?
So great to see that Fabiolas Review is now published in Frontiers in Immunology.
In the article we review the interaction between diet, microbiota, and host defense peptides, including antimicrobial peptides, at the intestinal mucosal barrier. We discuss how HDP expression can be modulated by specific microbes and their metabolites as well as by dietary factors, including fibers, lipids, polyphenols and vitamins. Also, we identify several dietary compounds that lead to reduced HDP function, but also factors that stimulate HDP production in the intestine.
NRSCID and a Biotech grant!
We are extremely happy that Fabiola has been selected to join the National Research School In Chronic Inflammatory Diseases for the upcoming years! The NRSCID is funded by the Swedish Council of Research and will provide high quality research training for PhD students in a clinical environment.
And even more good news: We were awarded a Basic Science-Oriented Biotechnology Research Grant from the Medial Faculty of Umeå University! The grant will support our research for the next two years.
I am honoured to be invited to join the Editorial Board of Gastroenterology Report , an international open access journal that covers all areas related to gastrointestinal sciences.
On that note, I am extremely happy to see that my Review on the interaction between gut microbiota and mucus function from February 2019 is still the most read article in that journal.
Beginning of February Paul Tetteh Asare joined the lab as a post-doc. He will work on intestinal mucus function and its relation with the gut microbiota.
Paul obtained a Bachelor in Agriculture in Cape-Coast, Ghana, and a Master in Food Science and Technology from Chonbuk National University in South Korea before doing his PhD in Food Biotechnology at the ETH Zurich in Switzerland. Now Paul moved up north to join the growing team in Umeå.
Welcome Hanna, Lotte and Dhirend!
Now it’s getting crowded! Mid of January Hanna Lee, Lotte Zandbergen and Dhirendra Singh joined the group. Hanna is a dietitian and a self-proclaimed food connoisseur from UC Davis/USA and will stay in the group as a guest researcher for 10 weeks. Lotte is studying Cardiovascular Research at the VU University in the Netherlands and will perform her Master thesis in the lab.
Dhirend is finishing his PhD on fungal infections at the University of Szeged in Hungary and now joins the lab as a post-doctoral fellow. Here in Umeå all three will focus on the effect of diet and gut microbiota on mucus function. Read more about the “new arrivals” in our Team section.
Mid of October Fabiola Puertolas-Balint joined the lab as a project assistant. She will work on intestinal antimicrobial peptides and their interaction with the gut microbiota.
After finishing her Bachelor in Pharmaceutical sciences in Puebla/Mexico Fabiola did her International Master in Innovative Medince in Groningen/Netherlands and Uppsala/Sweden and now already started her first experiments here in Umeå.
We have been featured in a nice portrait in Västerbottens-Kuriren, Norrlands biggest daily news paper. Really great to see that our research is interesting for the community up here.
If you are interested, you can find the article here (in Swedish).
The setting-up of the lab is still continuing, but we are on a good way. Top candidates for the positions mentioned below have been invited and partly selected, so we are not actively recruiting post-docs and PhD students at the moment. But of course, it might be possible to join the lab with own independent funding.
From spring 2019, the Schroeder lab will be based at The Laboratory for Molecular Infection Medicine Sweden (MIMS) within the Nordic EMBL Partnership for Molecular Medicine, located at Umeå University at the beautiful east coast of Sweden. Our focus will be on the interaction between diet, gut microbiota and the intestinal immune system.
We are currently recruiting postdocs, one PhD student and motivated students. Please check our recruitment ads for details!